Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition

Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition

The retrotransposon long interspersed nuclear element-1 (LINE-1) can autonomously increase its copy number within a host genome through the retrotransposition process. LINE-1 is active in the germline and in neural progenitor cells, and its somatic retrotransposition activity has a broad impact on n...

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Bibliographic Details
Main Authors: Ryota Kuroki, Yui Murata, Satoshi Fuke, Yutaka Nakachi, Jun Nakashima, Gregory C. Kujoth, Tomas A. Prolla, Miki Bundo, Tadafumi Kato, Kazuya Iwamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Genetics
Subjects:
retrotransposition
mitochondrial DNA
non-LTR
basal ganglia
somatic mosaicism
POLG
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.519206/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.519206/full

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