miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level

miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level

<p>Abstract</p> <p>Background</p> <p>miR-15a and miR-16-1(miR-15a/16-1) have been implicated as tumor suppressors in chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemic cells. However the mechanism of inhibiting the proliferation of leukemic cells...

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Bibliographic Details
Main Authors: Gao Shen-meng, Xing Chong-yun, Chen Chi-qi, Lin Si-si, Dong Pei-hong, Yu Fu-jun
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
WT1
miR-15a
miR-16-1
proliferation
Online Access:http://www.jeccr.com/content/30/1/110

Internet

http://www.jeccr.com/content/30/1/110

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