The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Yet its mechanism of action is still poorly understood. In...

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Bibliographic Details
Main Authors: Anaïs Lalève, Cindy Vallières, Marie-Pierre Golinelli-Cohen, Cécile Bouton, Zehua Song, Grzegorz Pawlik, Sarah M. Tindall, Simon V. Avery, Jérôme Clain, Brigitte Meunier
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Redox Biology
Subjects:
Mitochondria
Malaria
Aconitase
Sod2
Oxidative stress
Yeast model
Primaquine
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715001597

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http://www.sciencedirect.com/science/article/pii/S2213231715001597

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