Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity

Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity

GBA1 gene encodes for the lysosomal membrane protein glucocerebrosidase (GCase). GBA1 heterozygous mutations profoundly impair GCase activity and are currently recognized as an important risk factor for the development of Parkinson's disease (PD). Deficits in lysosomal degradation pathways may...

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Bibliographic Details
Main Authors: Liudmila Mus, Francesca Siani, Claudio Giuliano, Christina Ghezzi, Silvia Cerri, Fabio Blandini
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Glucocerebrosidase
α-Synuclein
CBE
MPTP
Parkinson's disease
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118307563

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http://www.sciencedirect.com/science/article/pii/S0969996118307563

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