p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.

Bibliographic Details
Main Authors: Ashwini Hinge, Juying Xu, Jose Javier, Eucabeth Mose, Sachin Kumar, Reuben Kapur, Edward F. Srour, Punam Malik, Bruce J. Aronow, Marie-Dominique Filippi
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14382

Internet

https://doi.org/10.1038/ncomms14382

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