Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Summary: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In this study, we used cell culture and mouse models...

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Bibliographic Details
Main Authors: Karolina Pircs, Rebecca Petri, Sofia Madsen, Per Ludvik Brattås, Romina Vuono, Daniella R. Ottosson, Isabelle St-Amour, Bob A. Hersbach, Monika Matusiak-Brückner, Sofia Hult Lundh, Åsa Petersén, Nicole Déglon, Sébastien S. Hébert, Malin Parmar, Roger A. Barker, Johan Jakobsson
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718311070

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http://www.sciencedirect.com/science/article/pii/S2211124718311070

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