Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid

Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid

All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and improve normal peripheral blood cell counts. In this context, we used a proteo...

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Bibliographic Details
Main Authors: Maria Hernandez-Valladares, Rebecca Wangen, Elise Aasebø, Håkon Reikvam, Frode S. Berven, Frode Selheim, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
acute myeloid leukemia
treatment
chemosensitivity
all-trans retinoic acid
valproic acid
histone deacetylase
Online Access:https://www.mdpi.com/2072-6694/13/9/2143

Internet

https://www.mdpi.com/2072-6694/13/9/2143

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