Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Objective: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...

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Bibliographic Details
Main Authors: Rafael Mayoral, Olivia Osborn, Joanne McNelis, Andrew M. Johnson, Da Young Oh, Cristina Llorente Izquierdo, Heekyung Chung, Pingping Li, Paqui G. Traves, Gautam Bandyopadhyay, Ariane R. Pessentheiner, Jachelle M. Ofrecio, Joshua R. Cook, Li Qiang, Domenico Accili, Jerrold M. Olefsky
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Molecular Metabolism
Subjects:
Obesity
SIRT1
PPAR03B3
Glucose homeostasis
Insulin resistance
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000435

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http://www.sciencedirect.com/science/article/pii/S2212877815000435

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