Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

Inhibition of mTOR by rapamycin has been shown to suppress seizures in TSC/PTEN genetic models. Rapamycin, when applied immediately before or after a neurological insult, also prevents the development of spontaneous recurrent seizures (epileptogenesis) in an acquired model. In the present study, we...

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Bibliographic Details
Main Authors: Xiaoxing Huang, Hailong Zhang, Jun Yang, Jingfan Wu, John McMahon, Yufan Lin, Zhonglian Cao, Michael Gruenthal, Yunfei Huang
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
mTOR
Rapamycin
Chronic seizure
Acquired epilepsy
Mossy fiber sprouting
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001865

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http://www.sciencedirect.com/science/article/pii/S0969996110001865

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