Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts

Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts

Angiotensin-(1-12) [Ang-(1-12)], an alternate substrate for tissue angiotensin II (Ang II) formation, underscores the importance of alternative renin-independent pathway(s) for the generation of angiotensins. Since renin enzymatic activity is species-specific, a transgenic model of hypertension due...

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Bibliographic Details
Main Authors: Carlos M. Ferrario, Jessica VonCannon, Sarfaraz Ahmad, Kendra N. Wright, Drew J. Roberts, Hao Wang, Tomohisa Yamashita, Leanne Groban, Che Ping Cheng, James F. Collawn, Louis J. Dell'Italia, Jasmina Varagic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
chymase
cardiac hypertrophy
hypertension
renin angiotensin system
transgenic rats
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00163/full

Internet

https://www.frontiersin.org/article/10.3389/fcvm.2019.00163/full

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