Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Abstract Background The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA) has been reported. However, the related mechanism is still poor understood. In this study, we deeply investigated the role of metformin in AAA pathophysiology. Methods Angiotensin II (Ang-II) was used to...

Full description

Bibliographic Details
Main Authors: Zhu Wang, Jingjing Guo, Xinqiang Han, Ming Xue, Wenming Wang, Lei Mi, Yuguo Sheng, Chao Ma, Jian Wu, Xuejun Wu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell & Bioscience
Subjects:
Metformin
AAA
PI3K/AKT/mTOR pathway
Autophagy pathway
ApoE −/− mice
Online Access:http://link.springer.com/article/10.1186/s13578-019-0332-9

Internet

http://link.springer.com/article/10.1186/s13578-019-0332-9

Similar Items