CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling

CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling

Abstract Background DNA-crosslinking agents like cisplatin and mitomycin C (MMC) are indispensible for the treatment of many solid malignancies. These anticancer drugs generate DNA interstrand crosslinks (ICLs) that cause cell death by blocking replication forks. Many factors counteracting ICL-induc...

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Bibliographic Details
Main Authors: Tamara Codilupi, Doreen Taube, Hanspeter Naegeli
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Chemotherapy
Cisplatin
Crosslink - CUL4 - Fanconi anemia
ssDNA
Online Access:http://link.springer.com/article/10.1186/s12885-019-6305-x

Internet

http://link.springer.com/article/10.1186/s12885-019-6305-x

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