Evolution of bacterial phosphoglycerate mutases: non-homologous isofunctional enzymes undergoing gene losses, gains and lateral transfers.

Evolution of bacterial phosphoglycerate mutases: non-homologous isofunctional enzymes undergoing gene losses, gains and lateral transfers.

The glycolytic phosphoglycerate mutases exist as non-homologous isofunctional enzymes (NISE) having independent evolutionary origins and no similarity in primary sequence, 3D structure, or catalytic mechanism. Cofactor-dependent PGM (dPGM) requires 2,3-bisphosphoglycerate for activity; cofactor-inde...

Full description

Bibliographic Details
Main Authors: Jeremy M Foster, Paul J Davis, Sylvine Raverdy, Marion H Sibley, Elisabeth A Raleigh, Sanjay Kumar, Clotilde K S Carlow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2964296?pdf=render

Internet

http://europepmc.org/articles/PMC2964296?pdf=render

Similar Items