1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity[S]

1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity[S]

A method is described that allows noninvasive identification and quantitative assessment of lipid classes present in sebaceous excretions in rodents. The method relies on direct high-field proton NMR analysis of common group lipid protons in deuterated organic solvent extracts of fur. Extracts from...

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Bibliographic Details
Main Authors: Purnima Khandelwal, Steven Stryker, Hannguang Chao, Nelly Aranibar, R. Michael Lawrence, Malavi Madireddi, Wenjun Zhao, Luping Chen, Michael D. Reily
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Journal of Lipid Research
Subjects:
metabolomics
skin lipid
fur sebum
fur lipid
sebum lipid
human sebum
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352433

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520352433

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