SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.

Bibliographic Details
Main Authors: Alyssa E. Johnson, Brian O. Orr, Richard D. Fetter, Armen J. Moughamian, Logan A. Primeaux, Ethan G. Geier, Jennifer S. Yokoyama, Bruce L. Miller, Graeme W. Davis
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20796-8

Internet

https://doi.org/10.1038/s41467-020-20796-8

Similar Items