E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.

E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, which is characterized by progressive motor dysfunction as well as non-motor symptoms. Pathological and genetic studies have demonstrated that α-synuclein (αSyn) plays key roles in the pathogenesis of PD. Although se...

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Bibliographic Details
Main Authors: Ryusuke Sakai, Mari Suzuki, Morio Ueyama, Toshihide Takeuchi, Eiko N Minakawa, Hideki Hayakawa, Kousuke Baba, Hideki Mochizuki, Yoshitaka Nagai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218261

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https://doi.org/10.1371/journal.pone.0218261

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