The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.

The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.

Tryptanthrin is a natural product which has been reported to have several medicinal properties. In this study, we tried to investigate the detailed molecular mechanism of its bromo analogue (TBr), a potent cytotoxic agent in the induction of cancer cell death. It was found that TBr primarily targets...

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Bibliographic Details
Main Authors: Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Malik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4226462?pdf=render

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http://europepmc.org/articles/PMC4226462?pdf=render

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