In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress

In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress

Abstract Background Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes. This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and tendons. Methods Tenocytes from normal Spr...

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Bibliographic Details
Main Authors: Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Ryosuke Kuroda
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
High glucose
Oxidative stress
Dehydroepiandrosterone
NADPH oxidase
Diabetic tendinopathy
Online Access:https://doi.org/10.1186/s12891-021-04398-z

Internet

https://doi.org/10.1186/s12891-021-04398-z

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