Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Abstract Background Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune status. Using splenocytes, we have shown memory CD4-T cells that expand following systemic immunostimulatory therapies undergo...

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Bibliographic Details
Main Authors: Gail D. Sckisel, Annie Mirsoian, Christine M. Minnar, Marka Crittenden, Brendan Curti, Jane Q. Chen, Bruce R. Blazar, Alexander D. Borowsky, Arta M. Monjazeb, William J. Murphy
Format: Article
Language:English
Published: BMJ Publishing Group 2017-04-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy
Cancer
PD-1
Bystander Activation
CD8
NKG2D
Online Access:http://link.springer.com/article/10.1186/s40425-017-0235-4

Internet

http://link.springer.com/article/10.1186/s40425-017-0235-4

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