Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches

Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches

Polio viral proteinase 2A performs several essential functions in genome replication. Its inhibition prevents viral replication, thus making it an excellent substrate for drug development. In this study, the three-dimensional structure of 2A protease was determined and optimized by homology modellin...

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Bibliographic Details
Main Authors: Amna Younus, Saba Munawar, Muhammad Faraz Bhatti, Aqsa Ikram, Faryal Mehwish Awan, Ishrat Jabeen, Nasar Virk, Hussnain Ahmed Janjua, Muhammad Arshad
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Genes
Subjects:
poliovirus 2A protease (PV2Apr°)
docking
single-nucleotide polymorphisms (SNPs)
non-synonymous SNPs (nsSNPs)
computational analysis
drug binding sites
stability changes
Online Access:http://www.mdpi.com/2073-4425/9/5/228

Internet

http://www.mdpi.com/2073-4425/9/5/228

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