Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

Abstract It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PYK2, is sorted into exosomes by HSP90 via...

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Bibliographic Details
Main Authors: Li Zhong, Dan Liao, Jingjing Li, Wenqiang Liu, Jingxuan Wang, Cuiling Zeng, Xin Wang, Zhiliang Cao, Ruhua Zhang, Miao Li, Kuntai Jiang, Yi-Xin Zeng, Jianhua Sui, Tiebang Kang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00414-1

Internet

https://doi.org/10.1038/s41392-020-00414-1

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