Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus

Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus

Human β-defensin 2 (hBD-2) is a potent antimicrobial peptide that participates in defense against invading bacteria. We recently showed that bacterial components and histamine, through histamine H4 receptor (H4R), are involved in the pathogenesis of the potentially malignant lesion, oral li...

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Bibliographic Details
Main Authors: Abdelhakim Salem, Rabeia Almahmoudi, Jaana Hagström, Holger Stark, Dan Nordström, Tuula Salo, Kari K. Eklund
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
histamine
histamine H4 receptor
human beta defensin 2
mast cells
inflammation
bacterial lipopolysaccharide (LPS)
OPMDs
oral epithelium
oral cancer
oral tongue squamous cell carcinoma
Online Access:https://www.mdpi.com/1422-0067/20/7/1780

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https://www.mdpi.com/1422-0067/20/7/1780

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