Mechanisms of autoantibody production in systemic lupus erythematosus

Mechanisms of autoantibody production in systemic lupus erythematosus

Autoantibodies against a panoply of self-antigens are seen in SLE, but only a few (anti-Sm/RNP, anti-Ro/La, anti-dsDNA) are common. The common lupus autoantigens are nucleic-acid complexes and levels of autoantibodies can be extraordinarily high. We explore why that is the case. Lupus is associat...

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Bibliographic Details
Main Authors: Shuhong eHan, Haoyang eZhuang, Stepan eShumyak, Lijun eYang, Westley H. Reeves
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Immunology
Subjects:
Autoantibodies
Immune Tolerance
Lupus Erythematosus, Systemic
innate immunity
B cells
TLR7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00228/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00228/full

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