Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors. Human MCF7 breast cancer cells “home” to the bones of immune deficient mice following intracardiac inoculation, but do not grow well and stain negatively for Ki67, thus...

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Bibliographic Details
Main Authors: Rachelle W. Johnson, Yao Sun, Patricia W. M. Ho, Audrey S. M. Chan, Jasmine A. Johnson, Nathan J. Pavlos, Natalie A. Sims, T. John Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
parathyroid hormone-related protein
cyclic AMP
MCF7
breast cancer
calcium signaling
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00241/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00241/full

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