CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T helper (Th) 1 cells into C57BL/6 mice (Thy1.2...

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Bibliographic Details
Main Authors: Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
CD4+ T helper cells
T helper 1 cells
antigenic recall
CD28 costimulation
cytokine secretion
mouse
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.01060/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.01060/full

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