Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain

Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain

Abstract Background Melatonin is a well-known potent endogenous antioxidant pharmacological agent with significant neuroprotective actions. Here in the current study, we explored the nuclear factor erythroid 2-related factor 2 (Nrf2) gene-dependent antioxidant mechanism underlying the neuroprotectiv...

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Bibliographic Details
Main Authors: Tahir Ali, Shafiq Ur Rehman, Fawad Ali Shah, Myeong Ok Kim
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Melatonin
Ethanol
Neurotoxicity
ROS/oxidative stress
Nuclear factor erythroid 2-related factor 2 (Nrf2)
p-NF-K-B/p-IKKβ pathway
Online Access:http://link.springer.com/article/10.1186/s12974-018-1157-x

Internet

http://link.springer.com/article/10.1186/s12974-018-1157-x

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