Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer

Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer

Abstract Homologous recombination (HR) is the primary pathway for repairing double-strand DNA breaks implicating in the development of cancer. RNAi-based knockdowns of BRCA1 and RAD51 in this pathway have been performed to investigate the resulting transcriptomic profiles. Here we propose a computat...

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Bibliographic Details
Main Authors: Yue Wang, Kenneth M. K. Mark, Matthew H. Ung, Arminja Kettenbach, Todd Miller, Wei Xu, Wenqing Cheng, Tian Xia, Chao Cheng
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Genome Medicine
Subjects:
Homologous recombination pathway
Gene knockdown profiles
Cell proliferation
Cancer prognosis
Neoadjuvant chemotherapy
Genomic instability
Online Access:http://link.springer.com/article/10.1186/s13073-016-0363-3

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http://link.springer.com/article/10.1186/s13073-016-0363-3

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