P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages

P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages

Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host macrophages, which might be a key mediator of v...

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Bibliographic Details
Main Authors: Tapas Kumar Nayak, Prabhudutta Mamidi, Subhransu Sekhar Sahoo, P. Sanjai Kumar, Chandan Mahish, Sanchari Chatterjee, Bharat Bhusan Subudhi, Soma Chattopadhyay, Subhasis Chattopadhyay
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Chikungunya
Alphavirus
MAPK
Macrophages
TNF
p38
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00786/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00786/full

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