Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts

Exogenous expression of Oct4, Sox2, Klf4, and cMyc forces mammalian somatic cells to adopt molecular and phenotypic characteristics of embryonic stem cells, commencing with the required suppression of lineage-associated genes (e.g., Thy1 in mouse). Although omitting cMyc from the reprogramming cockt...

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Bibliographic Details
Main Authors: Corey Heffernan, Huseyin Sumer, Luis F. Malaver-Ortega, Paul J. Verma
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2012/541014