Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36

Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36

Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100–1000 nm vesicles shed from injured cells that are implicated in intercellular signalling....

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Bibliographic Details
Main Authors: Mercedes N. Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E. Holterman, Rania Nasrallah, Richard L. Hébert, Christopher R. J. Kennedy, Dylan Burger
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Extracellular vesicles
microparticles
fibrosis
podocytes
proximal tubule
CD36
TGF-β
epithelial cells
Online Access:http://dx.doi.org/10.1080/20013078.2018.1432206

Internet

http://dx.doi.org/10.1080/20013078.2018.1432206

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