The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting potential and repolarizing action potentials. As volta...

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Bibliographic Details
Main Authors: Francisco Barros, Pilar de la Peña, Pedro Domínguez, Luisa Maria Sierra, Luis A. Pardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
potassium channel
EAG family
voltage-dependent gating
cytoplasmic domains
allosteric gating
structure-function relationships
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00411/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00411/full

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