Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report

Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report

Genetic and transcriptional heterogeneity of Chronic lymphocytic leukaemia (CLL) limits prevention of disease progression. Longitudinal single-cell transcriptomics represents the state-of-the-art method to profile the disease heterogeneity at diagnosis and to inform about disease evolution. Here, we...

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Bibliographic Details
Main Authors: Pavel Ostasov, Henry Robertson, Paolo Piazza, Avik Datta, Jane Apperley, Lucie Houdova, Daniel Lysak, Monika Holubova, Katerina Tesarova, Valentina S. Caputo, Iros Barozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
chronic lymphoid leukemia (CLL)
single-cell RNA-seq (scRNA-seq)
therapy resistance
disease progression
advanced disease
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.584607/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.584607/full

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