Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4<sup>+</sup> T Cells

Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4<sup>+</sup> T Cells

While CAR-T therapy is a growing and promising area of cancer research, it is limited by high cost and the difficulty of consistently culturing T-cells to therapeutically relevant concentrations ex-vivo. Cytokines IL-2, IL-7 and IL-15 have been found to stimulate the growth of T cells, however, the...

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Bibliographic Details
Main Authors: Canaan Coppola, Brooks Hopkins, Steven Huhn, Zhimei Du, Zuyi Huang, William J. Kelly
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
RNA sequencing
activated CD4<sup>+</sup> T cell
interleukin-2
interleukin-7
interleukin-15
Online Access:https://www.mdpi.com/1422-0067/21/21/7814

Internet

https://www.mdpi.com/1422-0067/21/21/7814

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