MYCN Function in Neuroblastoma Development

MYCN Function in Neuroblastoma Development

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a single oncogenic driver inducing neoplastic transformation in neural crest-derived cells. This abnormal MYCN expression is o...

Full description

Bibliographic Details
Main Authors: Jörg Otte, Cecilia Dyberg, Adena Pepich, John Inge Johnsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
MYCN
neuroblastoma
childhood cancer
neural crest
cancer stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.624079/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.624079/full

Similar Items