Wilm’s tumor 1 promotes memory flexibility

Wilm’s tumor 1 promotes memory flexibility

Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

Bibliographic Details
Main Authors: Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M. Seco, Nikos Tzavaras, Jens Hansen, Sarah A. Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U. Azeloglu, Georgia E. Hodes, Scott J. Russo, Vicki Huff, Marc R. Birtwistle, Robert D. Blitzer, Cristina M. Alberini, Ravi Iyengar
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11781-x

Internet

https://doi.org/10.1038/s41467-019-11781-x

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