Wilm’s tumor 1 promotes memory flexibility

Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

Bibliographic Details
Main Authors:	Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M. Seco, Nikos Tzavaras, Jens Hansen, Sarah A. Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U. Azeloglu, Georgia E. Hodes, Scott J. Russo, Vicki Huff, Marc R. Birtwistle, Robert D. Blitzer, Cristina M. Alberini, Ravi Iyengar
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11781-x

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spelling	doaj-aaada62663944bd6bb6bd2a1e13d925c2021-05-11T12:26:25ZengNature Publishing GroupNature Communications2041-17232019-08-0110111810.1038/s41467-019-11781-xWilm’s tumor 1 promotes memory flexibilityChiara Mariottini0Leonardo Munari1Ellen Gunzel2Joseph M. Seco3Nikos Tzavaras4Jens Hansen5Sarah A. Stern6Virginia Gao7Hossein Aleyasin8Ali Sharma9Evren U. Azeloglu10Georgia E. Hodes11Scott J. Russo12Vicki Huff13Marc R. Birtwistle14Robert D. Blitzer15Cristina M. Alberini16Ravi Iyengar17Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Genetics, M.D. Anderson Cancer Center, University of TexasDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiImpairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.https://doi.org/10.1038/s41467-019-11781-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar
spellingShingle	Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar Wilm’s tumor 1 promotes memory flexibility Nature Communications
author_facet	Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar
author_sort	Chiara Mariottini
title	Wilm’s tumor 1 promotes memory flexibility
title_short	Wilm’s tumor 1 promotes memory flexibility
title_full	Wilm’s tumor 1 promotes memory flexibility
title_fullStr	Wilm’s tumor 1 promotes memory flexibility
title_full_unstemmed	Wilm’s tumor 1 promotes memory flexibility
title_sort	wilm’s tumor 1 promotes memory flexibility
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.
url	https://doi.org/10.1038/s41467-019-11781-x
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Wilm’s tumor 1 promotes memory flexibility

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