Wilm’s tumor 1 promotes memory flexibility
Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.
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2019-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11781-x |
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doaj-aaada62663944bd6bb6bd2a1e13d925c2021-05-11T12:26:25ZengNature Publishing GroupNature Communications2041-17232019-08-0110111810.1038/s41467-019-11781-xWilm’s tumor 1 promotes memory flexibilityChiara Mariottini0Leonardo Munari1Ellen Gunzel2Joseph M. Seco3Nikos Tzavaras4Jens Hansen5Sarah A. Stern6Virginia Gao7Hossein Aleyasin8Ali Sharma9Evren U. Azeloglu10Georgia E. Hodes11Scott J. Russo12Vicki Huff13Marc R. Birtwistle14Robert D. Blitzer15Cristina M. Alberini16Ravi Iyengar17Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Genetics, M.D. Anderson Cancer Center, University of TexasDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiImpairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.https://doi.org/10.1038/s41467-019-11781-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar |
spellingShingle |
Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar Wilm’s tumor 1 promotes memory flexibility Nature Communications |
author_facet |
Chiara Mariottini Leonardo Munari Ellen Gunzel Joseph M. Seco Nikos Tzavaras Jens Hansen Sarah A. Stern Virginia Gao Hossein Aleyasin Ali Sharma Evren U. Azeloglu Georgia E. Hodes Scott J. Russo Vicki Huff Marc R. Birtwistle Robert D. Blitzer Cristina M. Alberini Ravi Iyengar |
author_sort |
Chiara Mariottini |
title |
Wilm’s tumor 1 promotes memory flexibility |
title_short |
Wilm’s tumor 1 promotes memory flexibility |
title_full |
Wilm’s tumor 1 promotes memory flexibility |
title_fullStr |
Wilm’s tumor 1 promotes memory flexibility |
title_full_unstemmed |
Wilm’s tumor 1 promotes memory flexibility |
title_sort |
wilm’s tumor 1 promotes memory flexibility |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-08-01 |
description |
Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility. |
url |
https://doi.org/10.1038/s41467-019-11781-x |
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