Cytotoxic 4-Hydroxyprorocentrolide and Prorocentrolide C from Cultured Dinoflagellate<i> Prorocentrum lima </i>Induce Human Cancer Cell Death through Apoptosis and Cell Cycle Arrest

Prorocentrolide and its analogs, the novel naturally derived antitumor agents, have recently been identified in the dinoflagellate <i>Prorocentrum lima</i>. In the current study, the underlying inhibitory mechanisms of 4-hydroxyprorocentrolide (<b>1</b>) and prorocentrolide C...

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Bibliographic Details
Main Authors: Seon Min Lee, Na-Hyun Kim, Eun Ju Jeong, Jung-Rae Rho
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/12/5/304