Prioritizing long range interactions in noncoding regions using GWAS and deletions perturbed TADs

Prioritizing long range interactions in noncoding regions using GWAS and deletions perturbed TADs

Genome-wide association studies (GWAS) have contributed significantly to predisposing the disease etiology by associating single nucleotide polymorphisms (SNPs) with complex diseases. However, most GWAS-SNPs are in the noncoding regions that may affect distal genes via long range enhancer-promoter i...

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Bibliographic Details
Main Authors: Xuanshi Liu, Wenjian Xu, Fei Leng, Chanjuan Hao, Sree Rohit Raj Kolora, Wei Li
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Noncoding region interpretation
Genome wide association study
Deletion
Topological associated domain
Enhancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304360

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http://www.sciencedirect.com/science/article/pii/S2001037020304360

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