The Predominant Pathway of Apoptosis in THP-1 Macrophage-Derived Foam Cells Induced by 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy is the Mitochondria-Caspase Pathway Despite the Participation of Endoplasmic Reticulum Stress

The Predominant Pathway of Apoptosis in THP-1 Macrophage-Derived Foam Cells Induced by 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy is the Mitochondria-Caspase Pathway Despite the Participation of Endoplasmic Reticulum Stress

Background: In advanced atherosclerosis, chronic endoplasmic reticulum (ER) stress induces foam cells apoptosis and generates inflammatory reactions. Methods: THP-1 macrophage-derived foam cells (FC) were incubated with 1 mM 5-aminolevulinic acid (ALA). After ALA mediated sonodynamic therapy (ALA-SD...

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Bibliographic Details
Main Authors: Huan Wang, Yang Yang, Haibo Chen, Juhua Dan, Jiali Cheng, Shuyuan Guo, Xin Sun, Wei Wang, Yiwei Ai, Shuchang Li, Zhixin Li, Li Peng, Zhen Tian, Liming Yang, Jichao Wu, Xin Zhong, Qi Zhou, Peng Wang, Zhiguo Zhang, Wenwu Cao, Ye Tian
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Foam cell
Apoptosis
5-aminolevulinic acid
Sonodynamic therapy
Mitochondria pathway
ER stress
Atherosclerosis
Reactive oxygen species
Online Access:http://www.karger.com/Article/FullText/362958

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http://www.karger.com/Article/FullText/362958

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