Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome

Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome

Down Syndrome (DS) is the most common genetic disorder associated with intellectual disability (ID). Excitatory neurons of DS patients and mouse models show decreased size of dendritic field and reduction of spine density. Whether these defects are caused by cell autonomous alterations or by abnorma...

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Bibliographic Details
Main Authors: Alessandra Maria Adelaide Chiotto, Martina Migliorero, Gianmarco Pallavicini, Federico Tommaso Bianchi, Marta Gai, Ferdinando Di Cunto, Gaia Elena Berto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
Down syndrome
neural differentiation
Ts65Dn
Ts2Cje
dendritic spines
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01081/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01081/full

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