Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice

Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice

The proinflammatory cytokine interleukin-1 (IL-1) is produced by many types of cells, including immune cells in the periphery and glia and neurons in the brain. The type I IL-1 receptor (IL-1r1) is primarily responsible for transmitting the inflammatory effects of IL-1 and mediates several biologica...

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Bibliographic Details
Main Authors: Takako Takemiya, Kumiko Fumizawa, Kanato Yamagata, Yoichiro Iwakura, Marumi Kawakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
interleukin-1β (IL-1β)
interleukin-1α (IL-1α)
IL-1β knockout mice (IL-1βko)
IL-1 receptor 1 (IL-1r1)
IL-1r1 knockout mice (IL-1r1ko)
water maze (WM)
Online Access:http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00202/full

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http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00202/full

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