Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis

While the importance of the iron-load of lipocalin-2 (Lcn-2) in promoting tumor progression is widely appreciated, underlying molecular mechanisms largely remain elusive. Considering its role as an iron-transporter, we aimed at clarifying iron-loaded, holo-Lcn-2 (hLcn-2)-dependent signaling pathways...

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Bibliographic Details
Main Authors: Julia K. Meier, Matthias Schnetz, Susanne Beck, Tobias Schmid, Monica Dominguez, Sanela Kalinovic, Andreas Daiber, Bernhard Brüne, Michaela Jung
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Metabolites
Subjects:
ROS
ISR
Online Access:https://www.mdpi.com/2218-1989/11/5/329