TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.

TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.

Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip⁻/⁻ mice are significantly more susceptible to lipo...

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Bibliographic Details
Main Authors: Young-Jun Park, Sung-Jin Yoon, Hyun-Woo Suh, Dong Oh Kim, Jeong-Ran Park, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Jeong-Ki Min, Hee-Jun Na, Seon-Jin Lee, Hee Gu Lee, Young Ho Lee, Hee-Bong Lee, Inpyo Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3789754?pdf=render

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http://europepmc.org/articles/PMC3789754?pdf=render

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