Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.

Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.

Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for...

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Bibliographic Details
Main Authors: John K Thuita, Kristina K Wolf, Grace A Murilla, Arlene S Bridges, David W Boykin, James N Mutuku, Qiang Liu, Susan K Jones, Charles O Gem, Shelley Ching, Richard R Tidwell, Michael Z Wang, Mary F Paine, Reto Brun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4318582?pdf=render

Internet

http://europepmc.org/articles/PMC4318582?pdf=render

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