A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer.

<label>BACKGROUND</label>Tumor cell fusion with motile bone marrow-derived cells (BMDCs) has long been posited as a mechanism for cancer metastasis. While there is much support for this from cell culture and animal studies, it has yet to be confirmed in human cancer, as tumor and marrow-...

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Bibliographic Details
Main Authors: Rossitza Lazova, Greggory S Laberge, Eric Duvall, Nicole Spoelstra, Vincent Klump, Mario Sznol, Dennis Cooper, Richard A Spritz, Joseph T Chang, John M Pawelek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3694119?pdf=render