Congenital Cytomegalovirus Infection: Maternal–Child HLA-C, HLA-E, and HLA-G Affect Clinical Outcome

Congenital Cytomegalovirus Infection: Maternal–Child HLA-C, HLA-E, and HLA-G Affect Clinical Outcome

Congenital CMV infection (cCMV) is the most common congenital infection causing permanent long-term impairments (LTI). cCMV immunopathogenesis is largely unknown due to the complex interplay between viral, maternal, placental, and child factors. In this study, a large retrospective nationwide cohort...

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Bibliographic Details
Main Authors: Roberta Rovito, Frans H. J. Claas, Geert W. Haasnoot, Dave L. Roelen, Aloys C. M. Kroes, Michael Eikmans, Ann C. T. M. Vossen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
mother–child HLA
congenital CMV infection
immunopathology
allo-reactivity
suboptimal viral clearance
NIMA effect
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01904/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01904/full

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