Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid

Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid

An excess of saturated fatty acids can be toxic for tissues, including the brain, and this has been associated with the progression of neurodegenerative diseases. Since palmitic acid (PA) is a free fatty acid that is abundant in the diet and circulation and can be harmful, we have investigated the e...

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Bibliographic Details
Main Authors: Laura M. Frago, Sandra Canelles, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Luis M. Garcia-Segura, Julie A. Chowen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
endoplasmic reticulum stress
palmitic acid
estradiol
hippocampus
astrocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00330/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00330/full

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