PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM cells to chemo-radiation is expected to extend surv...

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Bibliographic Details
Main Authors: Shiv K. Gupta, Emily J. Smith, Ann C. Mladek, Shulan Tian, Paul A. Decker, Sani H. Kizilbash, Gaspar J. Kitange, Jann N. Sarkaria
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
PARP (poly(ADP-ribose) polymerase
chemo-radiation sensitivity
DNA Damage
replication stress
DNA repair activity
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00670/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00670/full

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