In Vitro Inhibition of Human UDP-Glucuronosyl-Transferase (UGT) Isoforms by Astaxanthin, β-Cryptoxanthin, Canthaxanthin, Lutein, and Zeaxanthin: Prediction of in Vivo Dietary Supplement-Drug Interactions

In Vitro Inhibition of Human UDP-Glucuronosyl-Transferase (UGT) Isoforms by Astaxanthin, β-Cryptoxanthin, Canthaxanthin, Lutein, and Zeaxanthin: Prediction of in Vivo Dietary Supplement-Drug Interactions

Despite the widespread use of the five major xanthophylls astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin as dietary supplements, there have been no studies regarding their inhibitory effects on hepatic UDP-glucuronosyltransferases (UGTs). Here, we evaluated the inhibitory potent...

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Bibliographic Details
Main Authors: Yu Fen Zheng, Jee Sun Min, Doyun Kim, Jung Bae Park, Sung-Wook Choi, Eun Seong Lee, Kun Na, Soo Kyung Bae
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
xanthophylls
β-cryptoxanthin
in vitro UGTs inhibition
in vitro-in vivo extrapolation
Online Access:http://www.mdpi.com/1420-3049/21/8/1052

Internet

http://www.mdpi.com/1420-3049/21/8/1052

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