Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population. Based on the molecular heterogeneity observed in this tumor type, personalized treatment is considered to substantially improve therapeutic o...

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Bibliographic Details
Main Authors: Johannes Gojo, Zdenek Pavelka, Danica Zapletalova, Maria T. Schmook, Lisa Mayr, Sibylle Madlener, Michal Kyr, Klara Vejmelkova, Martin Smrcka, Thomas Czech, Christian Dorfer, Jarmila Skotakova, Amedeo A. Azizi, Monika Chocholous, Dominik Reisinger, David Lastovicka, Dalibor Valik, Christine Haberler, Andreas Peyrl, Hana Noskova, Karol Pál, Marta Jezova, Renata Veselska, Sarka Kozakova, Ondrej Slaby, Irene Slavc, Jaroslav Sterba
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
diffuse midline glioma
H3K27M
pediatric oncology
precision medicine
comprehensive molecular profiling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01436/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01436/full

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